UVA Health

Precision Breast IORT

Investigational Treatment Option for Early-Stage Breast Cancer

Precision Breast IORT (intraoperative radiation therapy) is an investigational treatment for early stage breast cancer that is available as part of a clinical trial and is unique to the University of Virginia.


Precision ​Breast IORT allows women with breast cancer to receive a single dose of personalized radiation at the same time as their breast surgery. Traditional breast-conserving therapy involves surgery (breast lumpectomy) and 4-6 weeks of daily radiation.


Find out if Precision Breast IORT is right for you. You must meet the following criteria in order to qualify:


  • Age 45 years or older
  • Tumor size less than 3 cm
  • No prior radiation treatment to the affected breast
  • New diagnosis of invasive breast cancer or ductal carcinoma in situ


Precision Breast IORT is part of a clinical trial.

IRB-HSR #18004

IRB# NCT002400658

PI: Shayna Showalter, MD

Find out if you qualify



Call us at 434.243.2027 if you have any questions.

What is Precision ​Breast IORT?

Traditional radiation therapy requires weeks of daily treatments. Breast IORT involves only one radiation dose at the time of breast surgery.

Unlike IORT available at other hospitals, Precision ​Breast IORT utilizes specialized CT image guidance and high dose rate brachytherapy to provide women with a single individualized radiation treatment.

Potential Benefits

Compared to traditional whole breast irradiation:

  • Better target volume coverage
  • Customized treatment plan allows the dose to be sculpted away from the heart, skin and ribs
  • Allows for delivery of higher dose of radiation to the area where the breast cancer was removed when compared to other forms of IORT
  • Patient convenience

Potential Risks

  • Bruising of the breast tissue, swelling or infection
  • Hardness or changes in the way the breast feels in the area that was treated

Don't qualify for IORT? Learn about other breast cancer treatment options at UVA.